Side Effects – Naltrexone


Naltrexone is a medication primarily used in the management of alcohol dependence and opioid addiction. Here are some common side effects of naltrexone:

  1. Gastrointestinal Issues:
    • These include nausea, vomiting, diarrhea, and abdominal pain. These symptoms are generally mild and often decrease over time as the body adjusts to the medication.
  2. Headache:
    • This is a frequently reported side effect, which can vary in intensity but is usually manageable.
  3. Fatigue and Drowsiness:
    • Some people may feel unusually tired or drowsy when taking naltrexone.
  4. Dizziness:
    • Patients may experience dizziness, which can increase the risk of falls, particularly in older adults.
  5. Joint and Muscle Pain:
    • Some individuals might feel muscle or joint pain while on the medication.
  6. Mood Changes:
    • Anxiety, nervousness, irritability, or depression can occur, which should be closely monitored by a healthcare provider.
  7. Insomnia:
    • Difficulty in falling or staying asleep is another potential side effect of naltrexone.
  8. Skin Reactions:
    • Rash or itching can occur, though it is less common.
  9. Decreased Appetite:
    • Some people might experience a reduced appetite or weight loss.
  10. Liver Damage:
    • Although rare, naltrexone can cause liver damage, particularly at higher doses. Patients on naltrexone usually have their liver function monitored through blood tests.