Drugs causing serotonin syndrome

Here is a list of drug classes and specific drugs associated with serotonin syndrome:

  1. Selective Serotonin Reuptake Inhibitors (SSRIs):
    1. Fluoxetine (Prozac, Lovan)
    2. Sertraline (Zoloft, Eleva)
    3. Paroxetine (Aropax, Paxtine)
    4. Citalopram (Celapram, Cipramil, Talam)
    5. Escitalopram (Lexapro, Esipram)
  2. Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs):
    1. Venlafaxine (Efexor)
    2. Duloxetine (Cymbalta)
    3. Desvenlafaxine (Pristiq)
  3. Monoamine Oxidase Inhibitors (MAOIs):
    1. Phenelzine (Nardil)
    2. Tranylcypromine (Parnate)
    3. Selegiline (Eldepryl)
  4. Tricyclic Antidepressants (TCAs):
    1. Amitriptyline (Endep, Tryptanol)
    2. Nortriptyline (Allegron)
    3. Clomipramine (Anafranil, Placil)
  5. Triptans (used for migraine):
    1. Sumatriptan (Imigran, Sumagran)
    2. Rizatriptan (Maxalt)
  6. Opioids:
    1. Pethidine
    2. Tramadol (Tramal, Zydol)
    3. Fentanyl (Durogesic)
  7. Amphetamines and Amphetamine-like Drugs:
    1. MDMA (Ecstasy, Molly, a recreational drug)
    2. Dexamphetamine (Dexedrine, Dexamphetamine)
    3. Methylphenidate (Ritalin, Concerta)
  8. Certain Antipsychotics and Antiemetics:
    1. Ondansetron (Zofran, Ondansetron AN)
    2. Metoclopramide (Maxolon, Pramin)
  9. Herbal Supplements:
    1. St. John’s Wort (available over the counter)
    2. Ginseng (available over the counter)
  10. Other Medications:
    1. Lithium (Quilonum, Lithicarb)
    2. Linezolid (Zyvox)
    3. Dextromethorphan (found in some cough syrups like Robitussin, Benadryl)
    4. L-tryptophan (a dietary supplement)

The risk of serotonin syndrome often increases when certain medications are combined.