Boyd Diagnostic Strategy

Emeritus Professor Graham Boyd was a man ahead of his time and a fundamental influence on my diagnostic approach. Vale Prof.

He wrote a textbook that started with the opening verse a Kipling Poem:

I keep six honest serving-men
(They taught me all I knew);
Their names are What and Why and When
And How and Where and Who.

Rudyard Kipling

Sadly his book never caught on, but his legacy as a teacher and mentor does. IMHO his approach continues to run rings around more popular alternatives such as the Murtagh PROMPT model.

Here, in his own words, is a summary of the approach. This is from back in the 1980s when holistic care and the bio-psycho-social approach were yet to become a thing.

The Four-Columned Approach to Clinical Diagnosis

One of the real problems in making clinical diagnosis is the amount of clinical information we have to digest, such that it is often difficult to see the wood for the trees. Accordingly, it is often hard to make a diagnosis all-of-a-piece ” by any “inductive ” or other process of reasoning. With experience you will learn to recognize different disease patterns and readily be able to make a clinical diagnosis in those cases. But pattern recognition is fraught with pitfalls because so often, individual cases depart significantly from the classical. Besides pattern recognition requires experience and so is of little value to those in learning. Also, it is often less than fully descriptive, e.g. ‘myocardial infarction’. Because of these factors, the approach here is to handle the clinical information within a small number of separate categories, each largely independent but which, when put together, severally, describe all aspects of the condition or diagnosis. The following are the four categories:

  • WHERE is the problem?
    • ANATOMICAL DIAGNOSIS = the anatomical system involved.
  • WHAT is the general pathological nature of the condition?
    • PATHOLOGICAL DIAGNOSIS = nature of the condition.
  • HOW does it affect the patient?
    • PHYSIOLOGICAL DIAGNOSIS = functional consequences of the condition.
  • WHY did the patient get it?
    • AETIOLOGICAL DIAGNOSIS = background cause.
    • Subsumed under this category is also the question of WHO has the condition and why it occurred WHEN it did.
      • The WHO relates to the type of patient concerned in particular to the social and psychological contexts of the presentation.
      • The WHEN aims to focus on its precipitating factors.

The value of the four-column approach is that it allows you to focus down within each category on much less than the total body of information and thereby gives you a much greater chance of reaching the correct conclusion. Each of the categories contributes, and when taken together, they severally describe all the elements of clinical diagnosis. By contrast, when the pattern-recogniser pins some off-the-rack diagnostic label on a patient, it so often lacks one or other of these categories, particularly the Functional and Aetiological ones. Thus we often hear that a patient has had an ‘acute myocardial infarct’ (Anatomical and general Pathological diagnoses), but where is the comment about how this has affected him functionally (did he have secondary heart failure or ventricular dysrhythmias for example?); and what were the long-term factors predisposing to his condition as well as the more recent ones precipitating it (Aetiological diagnosis) – in this case was there preexisting hypertension predisposing to atheroma and some stressful life event precipitating the episode itself?

The present approach allows you to ‘tailor-make’ a diagnosis (Dx) to the individual patient as you go along rather than force him into some pre-conceived diagnostic pigeonhole read about in some textbook.

Implementation of the Boyd Method

The implementation of this diagnostic model is quite simple. Let’s use chest pain as an example.

Where?

Here we think about the anatomical structures present where the pain is, so for chest pain, we think outside to inside and list:

  • Skin
  • Subcutaneous Tissue
  • Muscles
  • Spine
  • Ribs and Costal Cartilage
  • Pleura
    • Parietal Pleura
    • Visceral Pleura
  • Lungs
  • Heart
    • Pericardium
    • Myocardium
    • Endocardium
  • Oesophagus
  • Aorta
  • Vena Cava
  • Mediastinum
    • Thymus
    • Lymph Nodes
    • Trachea and Bronchi
  • Nerves

What?

Here we consider what pathological processes that can occur and are informed by the VINDICATED MEN mnemonic.

  • Vascular
  • Infection / Inflammation
  • Neoplasm
  • Drugs
  • Iatrogenic / Idiopathic
  • Congenital / Genetic
  • Autoimmune / Allergic
  • Trauma / Tubes
  • Endocrine
  • Deficiencies / Excesses / Degenerative
  • Musculoskeletal / Metabolic (OSA, Obesity)
  • Environmental (Toxins, SNAP, Domestic Abuse)
  • Neuropsychiatric / NAI (Non-Accidental Injury)

How?

Here, we synthesize the anatomy and pathology into a theory about how this pain has happened, i.e., a differential diagnosis list, and magic starts to happen.

Skin

  • Vascular: Vasculitis
  • Infection / Inflammation: Cellulitis, herpes zoster
  • Neoplasm: Melanoma, squamous cell carcinoma
  • Drugs: Drug eruptions
  • Iatrogenic / Idiopathic: Surgical scars, contact dermatitis
  • Congenital / Genetic: Birthmarks, genetic skin disorders
  • Autoimmune / Allergic: Psoriasis, eczema
  • Trauma / Tubes: Lacerations, abrasions
  • Endocrine: Diabetic dermopathy
  • Deficiencies / Excesses / Degenerative: Pressure ulcers
  • Musculoskeletal / Metabolic: Obesity-related skin folds
  • Environmental: Toxin exposure, sunburn
  • Neuropsychiatric / NAI: Self-harm, physical abuse

Subcutaneous Tissue

  • Vascular: Hematoma
  • Infection / Inflammation: Abscess
  • Neoplasm: Lipoma, sarcoma
  • Drugs: Injection site reactions
  • Iatrogenic / Idiopathic: Post-surgical changes
  • Congenital / Genetic: Lipodystrophy
  • Autoimmune / Allergic: Panniculitis
  • Trauma / Tubes: Contusions
  • Endocrine: Insulin lipodystrophy
  • Deficiencies / Excesses / Degenerative: Fat necrosis
  • Musculoskeletal / Metabolic: None specific
  • Environmental: Toxin exposure
  • Neuropsychiatric / NAI: Self-inflicted injuries, physical abuse

Muscles

  • Vascular: Compartment syndrome
  • Infection / Inflammation: Myositis
  • Neoplasm: Rhabdomyosarcoma
  • Drugs: Statin-induced myopathy
  • Iatrogenic / Idiopathic: Post-surgical pain
  • Congenital / Genetic: Muscular dystrophy
  • Autoimmune / Allergic: Polymyositis
  • Trauma / Tubes: Muscle strain, tears
  • Endocrine: Hyperthyroid myopathy
  • Deficiencies / Excesses / Degenerative: Sarcopenia
  • Musculoskeletal / Metabolic: Obesity-related musculoskeletal pain
  • Environmental: Toxin exposure
  • Neuropsychiatric / NAI: Stress-related muscle tension, abuse

Spine

  • Vascular: Vertebral artery dissection
  • Infection / Inflammation: Vertebral osteomyelitis
  • Neoplasm: Spinal metastasis
  • Drugs: Corticosteroid-induced osteoporosis
  • Iatrogenic / Idiopathic: Failed back surgery syndrome
  • Congenital / Genetic: Spina bifida
  • Autoimmune / Allergic: Ankylosing spondylitis
  • Trauma / Tubes: Fractures
  • Endocrine: Osteoporotic fractures
  • Deficiencies / Excesses / Degenerative: Degenerative disc disease
  • Musculoskeletal / Metabolic: Obesity-related spine stress
  • Environmental: Toxin exposure
  • Neuropsychiatric / NAI: Chronic pain syndromes, abuse

Ribs and Costal Cartilage

  • Vascular: Rib infarction in sickle cell disease
  • Infection / Inflammation: Costochondritis
  • Neoplasm: Rib tumors
  • Drugs: Chemotherapy-induced rib pain
  • Iatrogenic / Idiopathic: Post-thoracotomy pain
  • Congenital / Genetic: Rib dysplasia
  • Autoimmune / Allergic: Rheumatoid arthritis affecting ribs
  • Trauma / Tubes: Rib fractures
  • Endocrine: Osteoporotic fractures
  • Deficiencies / Excesses / Degenerative: Degenerative joint disease
  • Musculoskeletal / Metabolic: None specific
  • Environmental: Toxin exposure
  • Neuropsychiatric / NAI: Physical abuse

Pleura

  • Vascular: Pulmonary embolism
  • Infection / Inflammation: Pleuritis
  • Neoplasm: Mesothelioma
  • Drugs: Drug-induced pleuritis
  • Iatrogenic / Idiopathic: Post-thoracentesis complications
  • Congenital / Genetic: Pleural cysts
  • Autoimmune / Allergic: Lupus pleuritis
  • Trauma / Tubes: Hemothorax
  • Endocrine: None specific
  • Deficiencies / Excesses / Degenerative: None specific
  • Musculoskeletal / Metabolic: None specific
  • Environmental: Asbestos exposure
  • Neuropsychiatric / NAI: None specific

Lungs

  • Vascular: Pulmonary embolism
  • Infection / Inflammation: Pneumonia
  • Neoplasm: Lung cancer
  • Drugs: Drug-induced pneumonitis
  • Iatrogenic / Idiopathic: Post-radiation fibrosis
  • Congenital / Genetic: Cystic fibrosis
  • Autoimmune / Allergic: Sarcoidosis
  • Trauma / Tubes: Pneumothorax
  • Endocrine: None specific
  • Deficiencies / Excesses / Degenerative: Chronic obstructive pulmonary disease (COPD)
  • Musculoskeletal / Metabolic: Obesity hypoventilation syndrome
  • Environmental: Toxin exposure, smoking
  • Neuropsychiatric / NAI: Anxiety-related hyperventilation

Heart

  • Vascular: Myocardial infarction
  • Infection / Inflammation: Endocarditis
  • Neoplasm: Cardiac tumors
  • Drugs: Chemotherapy-induced cardiomyopathy
  • Iatrogenic / Idiopathic: Post-cardiac surgery complications
  • Congenital / Genetic: Congenital heart defects
  • Autoimmune / Allergic: Rheumatic heart disease
  • Trauma / Tubes: Cardiac contusion
  • Endocrine: Thyroid-induced cardiomyopathy
  • Deficiencies / Excesses / Degenerative: Coronary artery disease
  • Musculoskeletal / Metabolic: Obesity-related heart disease
  • Environmental: Toxin exposure, substance abuse
  • Neuropsychiatric / NAI: Stress cardiomyopathy

Oesophagus

  • Vascular: Esophageal varices
  • Infection / Inflammation: Esophagitis
  • Neoplasm: Esophageal cancer
  • Drugs: Pill esophagitis
  • Iatrogenic / Idiopathic: Post-endoscopy perforation
  • Congenital / Genetic: Esophageal atresia
  • Autoimmune / Allergic: Eosinophilic esophagitis
  • Trauma / Tubes: Boerhaave syndrome
  • Endocrine: None specific
  • Deficiencies / Excesses / Degenerative: Achalasia
  • Musculoskeletal / Metabolic: None specific
  • Environmental: Toxin ingestion
  • Neuropsychiatric / NAI: Eating disorders

Aorta

  • Vascular: Aortic dissection
  • Infection / Inflammation: Aortitis
  • Neoplasm: None specific
  • Drugs: None specific
  • Iatrogenic / Idiopathic: Post-surgical complications
  • Congenital / Genetic: Marfan syndrome
  • Autoimmune / Allergic: Takayasu arteritis
  • Trauma / Tubes: Traumatic aortic rupture
  • Endocrine: None specific
  • Deficiencies / Excesses / Degenerative: Atherosclerosis
  • Musculoskeletal / Metabolic: None specific
  • Environmental: None specific
  • Neuropsychiatric / NAI: None specific

Vena Cava

  • Vascular: Superior vena cava syndrome
  • Infection / Inflammation: Thrombophlebitis
  • Neoplasm: Compression by tumor
  • Drugs: None specific
  • Iatrogenic / Idiopathic: Central line complications
  • Congenital / Genetic: Congenital vena cava anomalies
  • Autoimmune / Allergic: None specific
  • Trauma / Tubes: Vena cava injury
  • Endocrine: None specific
  • Deficiencies / Excesses / Degenerative: None specific
  • Musculoskeletal / Metabolic: None specific
  • Environmental: None specific
  • Neuropsychiatric / NAI: None specific

Mediastinum

  • Vascular: Mediastinal hematoma
  • Infection / Inflammation: Mediastinitis
  • Neoplasm: Thymoma
  • Drugs: None specific
  • Iatrogenic / Idiopathic: Post-surgical mediastinitis
  • Congenital / Genetic: Mediastinal cysts
  • Autoimmune / Allergic: Sarcoidosis
  • Trauma / Tubes: Mediastinal injury
  • Endocrine: None specific
  • Deficiencies / Excesses / Degenerative: None specific
  • Musculoskeletal / Metabolic: None specific
  • Environmental: None specific
  • Neuropsychiatric / NAI: None specific

Nerves

  • Vascular: Nerve infarction
  • Infection / Inflammation: Neuritis
  • Neoplasm: Neurofibroma
  • Drugs: Chemotherapy-induced neuropathy
  • Iatrogenic / Idiopathic: Post-surgical nerve injury
  • Congenital / Genetic: Charcot-Marie-Tooth disease
  • Autoimmune / Allergic: Guillain-Barré syndrome
  • Trauma / Tubes: Nerve laceration
  • Endocrine: Diabetic neuropathy
  • Deficiencies / Excesses / Degenerative: Vitamin B12 deficiency neuropathy
  • Musculoskeletal / Metabolic: Metabolic neuropathy
  • Environmental: Toxin-induced neuropathy
  • Neuropsychiatric / NAI: Psychogenic pain, abuse

Now, if I asked you to create a list of the causes of chest pain, you could almost certainly rattle off 10-20-30 or perhaps even more. With three tools

  1. The anatomical question “Where?”,
  2. The pathological question “What?” and
  3. The synthesis question “How?”

No list learning required – just take some basic anatomy, add some basic pathology and ask the question “How?” Add a bit of experience around the names of our various diseases and we have generated 145 possibilities:

  1. Abrasions
  2. Abscess
  3. Abuse
  4. Achalasia
  5. Ankylosing Spondylitis
  6. Anxiety-Related Hyperventilation
  7. Aortic Dissection
  8. Aortitis
  9. Asbestos Exposure
  10. Atherosclerosis
  11. Birthmarks
  12. Boerhaave Syndrome
  13. Cardiac Contusion
  14. Cardiac Tumors
  15. Cellulitis
  16. Central Line Complications
  17. Charcot-Marie-Tooth Disease
  18. Chemotherapy-Induced Cardiomyopathy
  19. Chemotherapy-Induced Neuropathy
  20. Chemotherapy-Induced Rib Pain
  21. Chronic Obstructive Pulmonary Disease (COPD)
  22. Chronic Pain Syndromes
  23. Compartment Syndrome
  24. Compression by Tumor
  25. Congenital Heart Defects
  26. Congenital Vena Cava Anomalies
  27. Contact Dermatitis
  28. Contusions
  29. Coronary Artery Disease
  30. Corticosteroid-Induced Osteoporosis
  31. Costochondritis
  32. Cystic Fibrosis
  33. Degenerative Disc Disease
  34. Degenerative Joint Disease
  35. Diabetic Dermopathy
  36. Diabetic Neuropathy
  37. Drug Eruptions
  38. Drug-Induced Pleuritis
  39. Drug-Induced Pneumonitis
  40. Eating Disorders
  41. Eczema
  42. Endocarditis
  43. Eosinophilic Esophagitis
  44. Esophageal Atresia
  45. Esophageal Cancer
  46. Esophageal Varices
  47. Esophagitis
  48. Failed Back Surgery Syndrome
  49. Fat Necrosis
  50. Fractures
  51. Genetic Skin Disorders
  52. Guillain-Barré Syndrome
  53. Hematoma
  54. Hemothorax
  55. Herpes Zoster
  56. Hyperthyroid Myopathy
  57. Injection Site Reactions
  58. Insulin Lipodystrophy
  59. Lacerations
  60. Lipodystrophy
  61. Lipoma
  62. Lung Cancer
  63. Lupus Pleuritis
  64. Marfan Syndrome
  65. Mediastinal Cysts
  66. Mediastinal Hematoma
  67. Mediastinal Injury
  68. Mediastinitis
  69. Melanoma
  70. Mesothelioma
  71. Metabolic Neuropathy
  72. Muscle Strain
  73. Muscle Tears
  74. Muscular Dystrophy
  75. Myocardial Infarction
  76. Myositis
  77. Nerve Infarction
  78. Nerve Laceration
  79. Neuritis
  80. Neurofibroma
  81. Obesity Hypoventilation Syndrome
  82. Obesity-Related Heart Disease
  83. Obesity-Related Musculoskeletal Pain
  84. Obesity-Related Skin Folds
  85. Obesity-Related Spine Stress
  86. Osteoporotic Fractures
  87. Panniculitis
  88. Physical Abuse
  89. Physical Abuse
  90. Pill Esophagitis
  91. Pleural Cysts
  92. Pleuritis
  93. Pneumonia
  94. Pneumothorax
  95. Polymyositis
  96. Post-Cardiac Surgery Complications
  97. Post-Endoscopy Perforation
  98. Post-Radiation Fibrosis
  99. Post-Surgical Changes
  100. Post-Surgical Complications
  101. Post-Surgical Mediastinitis
  102. Post-Surgical Nerve Injury
  103. Post-Surgical Pain
  104. Post-Thoracentesis Complications
  105. Post-Thoracotomy Pain
  106. Pressure Ulcers
  107. Psoriasis
  108. Psychogenic Pain
  109. Pulmonary Embolism
  110. Rhabdomyosarcoma
  111. Rheumatic Heart Disease
  112. Rheumatoid Arthritis Affecting Ribs
  113. Rib Dysplasia
  114. Rib Fractures
  115. Rib Infarction in Sickle Cell Disease
  116. Rib Tumors
  117. Sarcoidosis
  118. Sarcoma
  119. Sarcopenia
  120. Self-Harm
  121. Self-Inflicted Injuries
  122. Smoking
  123. Spina Bifida
  124. Spinal Metastasis
  125. Squamous Cell Carcinoma
  126. Statin-Induced Myopathy
  127. Stress Cardiomyopathy
  128. Stress-Related Muscle Tension
  129. Substance Abuse
  130. Sunburn
  131. Superior Vena Cava Syndrome
  132. Surgical Scars
  133. Takayasu Arteritis
  134. Thrombophlebitis
  135. Thymoma
  136. Thyroid-Induced Cardiomyopathy
  137. Toxin Exposure
  138. Toxin Ingestion
  139. Toxin-Induced Neuropathy
  140. Traumatic Aortic Rupture
  141. Vasculitis
  142. Vena Cava Injury
  143. Vertebral Artery Dissection
  144. Vertebral Osteomyelitis
  145. Vitamin B12 Deficiency Neuropathy

Why?

Here we ask 3 questions:

  • Why is this patient getting chest pain, i.e. what is the differential diagnosis and the most likely diagnosis?
  • Who is the patient, and in particular, what is their social and psychological context and how does it impact their life?
  • When did it start, and what precipitated it?

You will note that for the vague symptom of chest pain, there is a huge range of possibilities, but many of these evaporate in the context of taking a thorough history, namely:

  1. Presenting Complaint (PC)
  2. Review of Systems (RoS), including Red Flags
  3. Medication History (MHx), including allergies
  4. Past Medical History (PHx)
  5. Family History (FHx)
  6. Social History (SHx)
  7. Travel and Exposure History (THx)
  8. Obstetric/Gynecological/Sexual History (OHx)
  9. Psychiatric History (PsychHx)
  10. Immunization and Preventive Care History (IHx)

Of these items, the History of the Presenting Complaint is often the most important.

  1. Site: Where in the body are the symptom(s) experienced?
  2. Character: Description of the primary symptom(s) or reason for seeking medical care.
  3. Radiation: Whether the symptom(s) spread to other areas.
  4. Onset: When the symptom(s) began or were first noticed.
  5. Duration: How long the symptom(s) have been present.
  6. Temporal Pattern: Any pattern or timing to the symptom(s), such as nocturnal or postprandial.
  7. Exacerbating/Relieving Factors: What makes the symptom(s) better or worse.
  8. Associated Symptoms: Other symptoms that accompany the main complaint.
  9. Severity: The severity of the symptom(s), often quantified (e.g., on a scale of 1-10).
    • How has this <problem> impacted your life?
  10. Patient Thinks: What does the patient think is going on?

You will note the use of a different order to the well-known SOCRATES. The rather ugly mnemonic SCRODTEAS-PT (SCR ODT EAS PT) groups things into logical sections:

  • Site – Character – Radiation: Where is the pain? What is it like? Does it go anywhere?
  • Onset – Duration – Temporal Pattern: When did it start? How long did it go on for? What is the time course of the pain?
  • Exacerbating/Relieving – Associated – Severity: Does anything make it better or worse? Is anything else going on? How bad is it?
    • Each item provides clues to the causation.
  • Patient Thinks: Important because the patient’s concerns are the reason they have presented.

The Beauty of the Boyd Method

In my opinion, medical education takes some of our best and brightest students, tries to stuff them full of facts, and turns them into unthinking protocol-driven robots.

The Boyd method says:

  1. Put your thinking cap back on
  2. Use what you know and synthesise your DDx
  3. Learn as you go

See one, do one, teach one.

Education debate: clinical diagnostic reasoning

Abstract

Whilst it is clear that experienced clinicians adopt a rational approach to diagnosis, the logic of their clinical reasoning has been difficult to define. I outline here an approach based on the four categories of a complete diagnosis: Anatomical diagnosis (system
involved); Pathological diagnosis (nature of the condition); Physiological diagnosis (functional consequences), and Aetiological diagnosis (background cause). Each phrase of the history and examination data is assigned to one or other of these categories as the
case unfolds, with interpretations and interactions allowing sub-conclusions that gradually build to a final clinical diagnosis overall. The system has the advantage of facilitating a diagnosis individualized to the patient rather than to some previously learned diagnostic ‘checklist’. As such, it should provide an advance over current problem-based approaches to clinical diagnosis.