Emeritus Professor Graham Boyd was a man ahead of his time and a fundamental influence on my diagnostic approach. Vale Prof.
He wrote a textbook that started with the opening verse a Kipling Poem:
I keep six honest serving-men
(They taught me all I knew);
Their names are What and Why and When
And How and Where and Who.
– Rudyard Kipling
Sadly his book never caught on, but his legacy as a teacher and mentor does. IMHO his approach continues to run rings around more popular alternatives such as the Murtagh PROMPT model.
Here, in his own words, is a summary of the approach. This is from back in the 1980s when holistic care and the bio-psycho-social approach were yet to become a thing.
The Four-Columned Approach to Clinical Diagnosis
One of the real problems in making clinical diagnosis is the amount of clinical information we have to digest, such that it is often difficult to see the wood for the trees. Accordingly, it is often hard to make a diagnosis all-of-a-piece ” by any “inductive ” or other process of reasoning. With experience you will learn to recognize different disease patterns and readily be able to make a clinical diagnosis in those cases. But pattern recognition is fraught with pitfalls because so often, individual cases depart significantly from the classical. Besides pattern recognition requires experience and so is of little value to those in learning. Also, it is often less than fully descriptive, e.g. ‘myocardial infarction’. Because of these factors, the approach here is to handle the clinical information within a small number of separate categories, each largely independent but which, when put together, severally, describe all aspects of the condition or diagnosis. The following are the four categories:
- WHERE is the problem?
- ANATOMICAL DIAGNOSIS = the anatomical system involved.
- WHAT is the general pathological nature of the condition?
- PATHOLOGICAL DIAGNOSIS = nature of the condition.
- HOW does it affect the patient?
- PHYSIOLOGICAL DIAGNOSIS = functional consequences of the condition.
- WHY did the patient get it?
- AETIOLOGICAL DIAGNOSIS = background cause.
- Subsumed under this category is also the question of WHO has the condition and why it occurred WHEN it did.
- The WHO relates to the type of patient concerned in particular to the social and psychological contexts of the presentation.
- The WHEN aims to focus on its precipitating factors.
The value of the four-column approach is that it allows you to focus down within each category on much less than the total body of information and thereby gives you a much greater chance of reaching the correct conclusion. Each of the categories contributes, and when taken together, they severally describe all the elements of clinical diagnosis. By contrast, when the pattern-recogniser pins some off-the-rack diagnostic label on a patient, it so often lacks one or other of these categories, particularly the Functional and Aetiological ones. Thus we often hear that a patient has had an ‘acute myocardial infarct’ (Anatomical and general Pathological diagnoses), but where is the comment about how this has affected him functionally (did he have secondary heart failure or ventricular dysrhythmias for example?); and what were the long-term factors predisposing to his condition as well as the more recent ones precipitating it (Aetiological diagnosis) – in this case was there preexisting hypertension predisposing to atheroma and some stressful life event precipitating the episode itself?
The present approach allows you to ‘tailor-make’ a diagnosis (Dx) to the individual patient as you go along rather than force him into some pre-conceived diagnostic pigeonhole read about in some textbook.
Implementation of the Boyd Method
The implementation of this diagnostic model is quite simple. Let’s use chest pain as an example.
Where?
Here we think about the anatomical structures present where the pain is, so for chest pain, we think outside to inside and list:
- Skin
- Subcutaneous Tissue
- Muscles
- Spine
- Ribs and Costal Cartilage
- Pleura
- Parietal Pleura
- Visceral Pleura
- Lungs
- Heart
- Pericardium
- Myocardium
- Endocardium
- Oesophagus
- Aorta
- Vena Cava
- Mediastinum
- Thymus
- Lymph Nodes
- Trachea and Bronchi
- Nerves
What?
Here we consider what pathological processes that can occur and are informed by the VINDICATED MEN mnemonic.
- Vascular
- Infection / Inflammation
- Neoplasm
- Drugs
- Iatrogenic / Idiopathic
- Congenital / Genetic
- Autoimmune / Allergic
- Trauma / Tubes
- Endocrine
- Deficiencies / Excesses / Degenerative
- —
- Musculoskeletal / Metabolic (OSA, Obesity)
- Environmental (Toxins, SNAP, Domestic Abuse)
- Neuropsychiatric / NAI (Non-Accidental Injury)
How?
Here, we synthesize the anatomy and pathology into a theory about how this pain has happened, i.e., a differential diagnosis list, and magic starts to happen.
Skin
- Vascular: Vasculitis
- Infection / Inflammation: Cellulitis, herpes zoster
- Neoplasm: Melanoma, squamous cell carcinoma
- Drugs: Drug eruptions
- Iatrogenic / Idiopathic: Surgical scars, contact dermatitis
- Congenital / Genetic: Birthmarks, genetic skin disorders
- Autoimmune / Allergic: Psoriasis, eczema
- Trauma / Tubes: Lacerations, abrasions
- Endocrine: Diabetic dermopathy
- Deficiencies / Excesses / Degenerative: Pressure ulcers
- Musculoskeletal / Metabolic: Obesity-related skin folds
- Environmental: Toxin exposure, sunburn
- Neuropsychiatric / NAI: Self-harm, physical abuse
Subcutaneous Tissue
- Vascular: Hematoma
- Infection / Inflammation: Abscess
- Neoplasm: Lipoma, sarcoma
- Drugs: Injection site reactions
- Iatrogenic / Idiopathic: Post-surgical changes
- Congenital / Genetic: Lipodystrophy
- Autoimmune / Allergic: Panniculitis
- Trauma / Tubes: Contusions
- Endocrine: Insulin lipodystrophy
- Deficiencies / Excesses / Degenerative: Fat necrosis
- Musculoskeletal / Metabolic: None specific
- Environmental: Toxin exposure
- Neuropsychiatric / NAI: Self-inflicted injuries, physical abuse
Muscles
- Vascular: Compartment syndrome
- Infection / Inflammation: Myositis
- Neoplasm: Rhabdomyosarcoma
- Drugs: Statin-induced myopathy
- Iatrogenic / Idiopathic: Post-surgical pain
- Congenital / Genetic: Muscular dystrophy
- Autoimmune / Allergic: Polymyositis
- Trauma / Tubes: Muscle strain, tears
- Endocrine: Hyperthyroid myopathy
- Deficiencies / Excesses / Degenerative: Sarcopenia
- Musculoskeletal / Metabolic: Obesity-related musculoskeletal pain
- Environmental: Toxin exposure
- Neuropsychiatric / NAI: Stress-related muscle tension, abuse
Spine
- Vascular: Vertebral artery dissection
- Infection / Inflammation: Vertebral osteomyelitis
- Neoplasm: Spinal metastasis
- Drugs: Corticosteroid-induced osteoporosis
- Iatrogenic / Idiopathic: Failed back surgery syndrome
- Congenital / Genetic: Spina bifida
- Autoimmune / Allergic: Ankylosing spondylitis
- Trauma / Tubes: Fractures
- Endocrine: Osteoporotic fractures
- Deficiencies / Excesses / Degenerative: Degenerative disc disease
- Musculoskeletal / Metabolic: Obesity-related spine stress
- Environmental: Toxin exposure
- Neuropsychiatric / NAI: Chronic pain syndromes, abuse
Ribs and Costal Cartilage
- Vascular: Rib infarction in sickle cell disease
- Infection / Inflammation: Costochondritis
- Neoplasm: Rib tumors
- Drugs: Chemotherapy-induced rib pain
- Iatrogenic / Idiopathic: Post-thoracotomy pain
- Congenital / Genetic: Rib dysplasia
- Autoimmune / Allergic: Rheumatoid arthritis affecting ribs
- Trauma / Tubes: Rib fractures
- Endocrine: Osteoporotic fractures
- Deficiencies / Excesses / Degenerative: Degenerative joint disease
- Musculoskeletal / Metabolic: None specific
- Environmental: Toxin exposure
- Neuropsychiatric / NAI: Physical abuse
Pleura
- Vascular: Pulmonary embolism
- Infection / Inflammation: Pleuritis
- Neoplasm: Mesothelioma
- Drugs: Drug-induced pleuritis
- Iatrogenic / Idiopathic: Post-thoracentesis complications
- Congenital / Genetic: Pleural cysts
- Autoimmune / Allergic: Lupus pleuritis
- Trauma / Tubes: Hemothorax
- Endocrine: None specific
- Deficiencies / Excesses / Degenerative: None specific
- Musculoskeletal / Metabolic: None specific
- Environmental: Asbestos exposure
- Neuropsychiatric / NAI: None specific
Lungs
- Vascular: Pulmonary embolism
- Infection / Inflammation: Pneumonia
- Neoplasm: Lung cancer
- Drugs: Drug-induced pneumonitis
- Iatrogenic / Idiopathic: Post-radiation fibrosis
- Congenital / Genetic: Cystic fibrosis
- Autoimmune / Allergic: Sarcoidosis
- Trauma / Tubes: Pneumothorax
- Endocrine: None specific
- Deficiencies / Excesses / Degenerative: Chronic obstructive pulmonary disease (COPD)
- Musculoskeletal / Metabolic: Obesity hypoventilation syndrome
- Environmental: Toxin exposure, smoking
- Neuropsychiatric / NAI: Anxiety-related hyperventilation
Heart
- Vascular: Myocardial infarction
- Infection / Inflammation: Endocarditis
- Neoplasm: Cardiac tumors
- Drugs: Chemotherapy-induced cardiomyopathy
- Iatrogenic / Idiopathic: Post-cardiac surgery complications
- Congenital / Genetic: Congenital heart defects
- Autoimmune / Allergic: Rheumatic heart disease
- Trauma / Tubes: Cardiac contusion
- Endocrine: Thyroid-induced cardiomyopathy
- Deficiencies / Excesses / Degenerative: Coronary artery disease
- Musculoskeletal / Metabolic: Obesity-related heart disease
- Environmental: Toxin exposure, substance abuse
- Neuropsychiatric / NAI: Stress cardiomyopathy
Oesophagus
- Vascular: Esophageal varices
- Infection / Inflammation: Esophagitis
- Neoplasm: Esophageal cancer
- Drugs: Pill esophagitis
- Iatrogenic / Idiopathic: Post-endoscopy perforation
- Congenital / Genetic: Esophageal atresia
- Autoimmune / Allergic: Eosinophilic esophagitis
- Trauma / Tubes: Boerhaave syndrome
- Endocrine: None specific
- Deficiencies / Excesses / Degenerative: Achalasia
- Musculoskeletal / Metabolic: None specific
- Environmental: Toxin ingestion
- Neuropsychiatric / NAI: Eating disorders
Aorta
- Vascular: Aortic dissection
- Infection / Inflammation: Aortitis
- Neoplasm: None specific
- Drugs: None specific
- Iatrogenic / Idiopathic: Post-surgical complications
- Congenital / Genetic: Marfan syndrome
- Autoimmune / Allergic: Takayasu arteritis
- Trauma / Tubes: Traumatic aortic rupture
- Endocrine: None specific
- Deficiencies / Excesses / Degenerative: Atherosclerosis
- Musculoskeletal / Metabolic: None specific
- Environmental: None specific
- Neuropsychiatric / NAI: None specific
Vena Cava
- Vascular: Superior vena cava syndrome
- Infection / Inflammation: Thrombophlebitis
- Neoplasm: Compression by tumor
- Drugs: None specific
- Iatrogenic / Idiopathic: Central line complications
- Congenital / Genetic: Congenital vena cava anomalies
- Autoimmune / Allergic: None specific
- Trauma / Tubes: Vena cava injury
- Endocrine: None specific
- Deficiencies / Excesses / Degenerative: None specific
- Musculoskeletal / Metabolic: None specific
- Environmental: None specific
- Neuropsychiatric / NAI: None specific
Mediastinum
- Vascular: Mediastinal hematoma
- Infection / Inflammation: Mediastinitis
- Neoplasm: Thymoma
- Drugs: None specific
- Iatrogenic / Idiopathic: Post-surgical mediastinitis
- Congenital / Genetic: Mediastinal cysts
- Autoimmune / Allergic: Sarcoidosis
- Trauma / Tubes: Mediastinal injury
- Endocrine: None specific
- Deficiencies / Excesses / Degenerative: None specific
- Musculoskeletal / Metabolic: None specific
- Environmental: None specific
- Neuropsychiatric / NAI: None specific
Nerves
- Vascular: Nerve infarction
- Infection / Inflammation: Neuritis
- Neoplasm: Neurofibroma
- Drugs: Chemotherapy-induced neuropathy
- Iatrogenic / Idiopathic: Post-surgical nerve injury
- Congenital / Genetic: Charcot-Marie-Tooth disease
- Autoimmune / Allergic: Guillain-Barré syndrome
- Trauma / Tubes: Nerve laceration
- Endocrine: Diabetic neuropathy
- Deficiencies / Excesses / Degenerative: Vitamin B12 deficiency neuropathy
- Musculoskeletal / Metabolic: Metabolic neuropathy
- Environmental: Toxin-induced neuropathy
- Neuropsychiatric / NAI: Psychogenic pain, abuse
Now, if I asked you to create a list of the causes of chest pain, you could almost certainly rattle off 10-20-30 or perhaps even more. With three tools
- The anatomical question “Where?”,
- The pathological question “What?” and
- The synthesis question “How?”
No list learning required – just take some basic anatomy, add some basic pathology and ask the question “How?” Add a bit of experience around the names of our various diseases and we have generated 145 possibilities:
- Abrasions
- Abscess
- Abuse
- Achalasia
- Ankylosing Spondylitis
- Anxiety-Related Hyperventilation
- Aortic Dissection
- Aortitis
- Asbestos Exposure
- Atherosclerosis
- Birthmarks
- Boerhaave Syndrome
- Cardiac Contusion
- Cardiac Tumors
- Cellulitis
- Central Line Complications
- Charcot-Marie-Tooth Disease
- Chemotherapy-Induced Cardiomyopathy
- Chemotherapy-Induced Neuropathy
- Chemotherapy-Induced Rib Pain
- Chronic Obstructive Pulmonary Disease (COPD)
- Chronic Pain Syndromes
- Compartment Syndrome
- Compression by Tumor
- Congenital Heart Defects
- Congenital Vena Cava Anomalies
- Contact Dermatitis
- Contusions
- Coronary Artery Disease
- Corticosteroid-Induced Osteoporosis
- Costochondritis
- Cystic Fibrosis
- Degenerative Disc Disease
- Degenerative Joint Disease
- Diabetic Dermopathy
- Diabetic Neuropathy
- Drug Eruptions
- Drug-Induced Pleuritis
- Drug-Induced Pneumonitis
- Eating Disorders
- Eczema
- Endocarditis
- Eosinophilic Esophagitis
- Esophageal Atresia
- Esophageal Cancer
- Esophageal Varices
- Esophagitis
- Failed Back Surgery Syndrome
- Fat Necrosis
- Fractures
- Genetic Skin Disorders
- Guillain-Barré Syndrome
- Hematoma
- Hemothorax
- Herpes Zoster
- Hyperthyroid Myopathy
- Injection Site Reactions
- Insulin Lipodystrophy
- Lacerations
- Lipodystrophy
- Lipoma
- Lung Cancer
- Lupus Pleuritis
- Marfan Syndrome
- Mediastinal Cysts
- Mediastinal Hematoma
- Mediastinal Injury
- Mediastinitis
- Melanoma
- Mesothelioma
- Metabolic Neuropathy
- Muscle Strain
- Muscle Tears
- Muscular Dystrophy
- Myocardial Infarction
- Myositis
- Nerve Infarction
- Nerve Laceration
- Neuritis
- Neurofibroma
- Obesity Hypoventilation Syndrome
- Obesity-Related Heart Disease
- Obesity-Related Musculoskeletal Pain
- Obesity-Related Skin Folds
- Obesity-Related Spine Stress
- Osteoporotic Fractures
- Panniculitis
- Physical Abuse
- Physical Abuse
- Pill Esophagitis
- Pleural Cysts
- Pleuritis
- Pneumonia
- Pneumothorax
- Polymyositis
- Post-Cardiac Surgery Complications
- Post-Endoscopy Perforation
- Post-Radiation Fibrosis
- Post-Surgical Changes
- Post-Surgical Complications
- Post-Surgical Mediastinitis
- Post-Surgical Nerve Injury
- Post-Surgical Pain
- Post-Thoracentesis Complications
- Post-Thoracotomy Pain
- Pressure Ulcers
- Psoriasis
- Psychogenic Pain
- Pulmonary Embolism
- Rhabdomyosarcoma
- Rheumatic Heart Disease
- Rheumatoid Arthritis Affecting Ribs
- Rib Dysplasia
- Rib Fractures
- Rib Infarction in Sickle Cell Disease
- Rib Tumors
- Sarcoidosis
- Sarcoma
- Sarcopenia
- Self-Harm
- Self-Inflicted Injuries
- Smoking
- Spina Bifida
- Spinal Metastasis
- Squamous Cell Carcinoma
- Statin-Induced Myopathy
- Stress Cardiomyopathy
- Stress-Related Muscle Tension
- Substance Abuse
- Sunburn
- Superior Vena Cava Syndrome
- Surgical Scars
- Takayasu Arteritis
- Thrombophlebitis
- Thymoma
- Thyroid-Induced Cardiomyopathy
- Toxin Exposure
- Toxin Ingestion
- Toxin-Induced Neuropathy
- Traumatic Aortic Rupture
- Vasculitis
- Vena Cava Injury
- Vertebral Artery Dissection
- Vertebral Osteomyelitis
- Vitamin B12 Deficiency Neuropathy
Why?
Here we ask 3 questions:
- Why is this patient getting chest pain, i.e. what is the differential diagnosis and the most likely diagnosis?
- Who is the patient, and in particular, what is their social and psychological context and how does it impact their life?
- When did it start, and what precipitated it?
You will note that for the vague symptom of chest pain, there is a huge range of possibilities, but many of these evaporate in the context of taking a thorough history, namely:
- Presenting Complaint (PC)
- Review of Systems (RoS), including Red Flags
- Medication History (MHx), including allergies
- Past Medical History (PHx)
- Family History (FHx)
- Social History (SHx)
- Travel and Exposure History (THx)
- Obstetric/Gynecological/Sexual History (OHx)
- Psychiatric History (PsychHx)
- Immunization and Preventive Care History (IHx)
Of these items, the History of the Presenting Complaint is often the most important.
- Site: Where in the body are the symptom(s) experienced?
- Character: Description of the primary symptom(s) or reason for seeking medical care.
- Radiation: Whether the symptom(s) spread to other areas.
- Onset: When the symptom(s) began or were first noticed.
- Duration: How long the symptom(s) have been present.
- Temporal Pattern: Any pattern or timing to the symptom(s), such as nocturnal or postprandial.
- Exacerbating/Relieving Factors: What makes the symptom(s) better or worse.
- Associated Symptoms: Other symptoms that accompany the main complaint.
- Severity: The severity of the symptom(s), often quantified (e.g., on a scale of 1-10).
- How has this <problem> impacted your life?
- Patient Thinks: What does the patient think is going on?
You will note the use of a different order to the well-known SOCRATES. The rather ugly mnemonic SCRODTEAS-PT (SCR ODT EAS PT) groups things into logical sections:
- Site – Character – Radiation: Where is the pain? What is it like? Does it go anywhere?
- Onset – Duration – Temporal Pattern: When did it start? How long did it go on for? What is the time course of the pain?
- Exacerbating/Relieving – Associated – Severity: Does anything make it better or worse? Is anything else going on? How bad is it?
- Each item provides clues to the causation.
- Patient Thinks: Important because the patient’s concerns are the reason they have presented.
The Beauty of the Boyd Method
In my opinion, medical education takes some of our best and brightest students, tries to stuff them full of facts, and turns them into unthinking protocol-driven robots.
The Boyd method says:
- Put your thinking cap back on
- Use what you know and synthesise your DDx
- Learn as you go
See one, do one, teach one.
Education debate: clinical diagnostic reasoning
Abstract
Whilst it is clear that experienced clinicians adopt a rational approach to diagnosis, the logic of their clinical reasoning has been difficult to define. I outline here an approach based on the four categories of a complete diagnosis: Anatomical diagnosis (system
involved); Pathological diagnosis (nature of the condition); Physiological diagnosis (functional consequences), and Aetiological diagnosis (background cause). Each phrase of the history and examination data is assigned to one or other of these categories as the
case unfolds, with interpretations and interactions allowing sub-conclusions that gradually build to a final clinical diagnosis overall. The system has the advantage of facilitating a diagnosis individualized to the patient rather than to some previously learned diagnostic ‘checklist’. As such, it should provide an advance over current problem-based approaches to clinical diagnosis.