Ramsay Hunt Syndrome

Ramsay Hunt Syndrome (RHS)

  • Cause:
    • RHS, also known as Herpes Zoster Oticus, is caused by the reactivation of the varicella-zoster virus (VZV) in the geniculate ganglion of the facial nerve.
    • It typically occurs in older adults or individuals with compromised immune systems.
  • Diagnosis:
    • History (Hx):
      • Sudden onset of painful, vesicular rash in the ear canal or on the auricle.
      • Facial paralysis or weakness on the same side as the rash.
      • Possible hearing loss, tinnitus, vertigo, or balance disturbances.
    • Examination (Ex):
      • Inspection of the ear for vesicular lesions.
      • Assessment of facial nerve function (facial droop, inability to close the eye, loss of forehead creases, etc.).
      • Evaluation for auditory and vestibular symptoms.
    • Investigations (Ix):
      • PCR testing of vesicle fluid or blood for VZV.
      • Audiometry if hearing loss is suspected.
      • MRI or CT scan may be needed to rule out other causes of facial paralysis.
  • Differential Diagnosis (DDx):
    • Bell’s Palsy (idiopathic facial nerve paralysis).
    • Middle ear infections.
    • Stroke.
  • Management (Mx):
    • Medications:
      • Antivirals: Acyclovir (Zovirax), Valacyclovir (Valtrex), or Famciclovir (Famvir) to reduce viral replication.
      • Corticosteroids: Prednisone to reduce inflammation and improve outcomes.
      • Analgesics: Pain relief for herpetic pain and post-herpetic neuralgia.
    • Supportive Care:
      • Eye care to prevent corneal damage (artificial tears, eye patch).
      • Physical therapy for facial muscles if paralysis is prolonged.

Postherpetic Neuralgia (PHN)

  • Cause:
    • PHN is a complication of shingles (Herpes Zoster), where pain persists in the area of the shingles rash long after the rash has healed.
    • It’s more common in older individuals and those with severe shingles.
  • Diagnosis:
    • History (Hx):
      • A history of shingles in the same location as the persistent pain.
      • Descriptions of pain type (burning, stabbing, etc.) and triggers.
    • Examination (Ex):
      • Inspect previously affected areas for post-inflammatory changes.
      • Sensory examination to check for altered sensation.
    • Investigations (Ix):
      • Usually a clinical diagnosis based on history and physical examination.
      • Rarely, skin biopsy or nerve conduction studies if the diagnosis is in doubt.
  • Differential Diagnosis (DDx):
    • Trigeminal neuralgia.
    • Diabetic neuropathy.
    • Complex regional pain syndrome.
  • Management (Mx):
    • Medications:
      • Gabapentanoid Anticonvulsants: Gabapentin (Neurontin) or Pregabalin (Lyrica) for neuropathic pain.
      • Tricyclic Antidepressants: Amitriptyline, Nortriptyline for neuropathic pain.
      • SNRI Antidepressants: Duloxetine for neuropathic pain.
      • Topical Agents: Lignocaine patches, capsaicin cream.
      • NSAID Analgesics: NSAID
      • Opiod Analgesics: For severe, refractory cases
    • Supportive Care:
      • Patient education about the nature of the condition.
      • Physical therapy or acupuncture may provide relief for some patients.
      • Patient education, close follow-up, and addressing comorbid conditions that might exacerbate symptoms (like stress or poor sleep) are important aspects of care.